The meeting of the seminar
in science, education and industry»
|Chairman of the organizing committee|
academician, rector of Lomonosov Moscow State University
Co-Chairs of the organizing committee
Corr. RAS, Director of Research Computing Center of Moscow State University
academician, dean of the faculty of Computational Mathematics and Cybernetics of Lomonosov Moscow State University
Scientific Secretary of the seminar
Ph.D., Research Computing Center of Moscow State University
The seminar was organized on the basis of the Scientific and Educational Center «Supercomputer Technologies». The reports cover all aspects of the use of supercomputers, parallel computing systems and distributed data processing methods for solving large computational problems. The seminar has a pronounced interdisciplinary nature, however, the various nuances of using supercomputer technologies are of interest to researchers from various fields.
The seminar is supported by the Moscow Center of Fundamental and Applied Mathematics.
|Shaitan A.K.||Associate Professor, Doctor of Physics and Mathematics, Department of Bioengineering, Faculty of Biology, Moscow State University|
Computer technologies and the problem of understanding the work of DNA in living systems
The complexity and power of modern computer information systems has reached impressive heights, they can compete in complexity with living organisms - the most complex objects created by nature. However, our understanding of how living systems function at the molecular level remains far from complete. The information content of genetic programs encoded by DNA in the human genome is less than 900 megabytes. However, a comprehensive understanding of the molecular mechanisms underlying the interpretation of these programs is a significant challenge that may be solved in the 21st century through a combination of high-performance automated experimental approaches and computer technology. The growing capabilities of modern computer systems and algorithms are ultimately a necessary component for solving this problem. In this talk, I will demonstrate how supercomputer modeling allows us to understand the molecular mechanisms of DNA functioning in living systems by understanding its dynamic interaction with proteins.
An article on supercomputer modeling of DNA packing into nucleosomes:
Armeev,G.A., Kniazeva,A.S., Komarova,G.A., Kirpichnikov,M.P. and Shaytan,A.K. (2021) Histone dynamics mediate DNA unwrapping and sliding in nucleosomes. Nat Commun., 12. https://www.nature.com/articles/s41467-021-22636-9
An article on the application of engineering approaches in biology:
Грешнова,А.А., Глухов,Г.С. and Шайтан,А.К. (2019) Синтетическая биология: конструирование живого. Химия и Жизнь - XXI век. https://engbio.ru/HiZ_9_2019_synbio.pdf
The seminar will be held in the form of a webinar on the Zoom platform.
To participate in the webinar, we ask you to enter your data in the Google spreadsheet:
A link to the Zoom conference will subsequently be sent to your email address.